ENOS-INDUCED VASCULAR BARRIER DISRUPTION IN RETINOPATHY BY C-SRC ACTIVATION AND TYROSINE PHOSPHORYLATION OF VE-CADHERIN

eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin

Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases.Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed.Methods: Oxygen-induced retinopathy was used as a model to test the role of nitric oxide (NO) in pathologica

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Estimating beam strength of metallic gear materials

Expressions for the pulsating or beam strengths of many popular metallic gear materials are derived based on the tensile strength and endurance ratio.The strength values predicted are for a reliability of 99% at load cycles corresponding Caps to that of the endurance strength of the materials.The expressions are based on the consideration of the re

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